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SIGMA XI - NJIT CHAPTER |
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"CAN'T WALK AND CHEW..." A DYNAMIC VIEW OF DNA REPAIR
Roman Osman, Ph.D.
Professor, Mount Sinai School of Medicine
ABSTRACT
DNA is continuously exposed to damaging agents and thus DNA repair is essential for survival. Recent structures of repair enzymes in complex with damaged DNA illustrate the distortion induced by the enzymes in establishing a specific repair complex. A combined computational and spectroscopic investigation of the vibrational and dynamic properties of DNA reveals the factors that distinguish damaged from native DNA. These factors constitute the basis for a high fidelity repair system.
BIOGRAPHY Roman Osman is a Professor at the Mt. Sinai School of Medicine. He has been President (1997-1999) and Vice President (1995-1997) of the International Society of Quantum Biology and Pharmacology, a Fullbright Fellow in Universidad Autonoma de Barcelona, Spain and received an Honorable Distinction for a Paper submitted to the IBM Supercomputer Paper Competition.
For information, contact Dr. Haim Grebel at (973)596-3538, grebel@njit.edu or Dr. Timothy Chang at (973)596-1906, changtn@njit.edu
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