Xiangxin Meng, of Edison, a doctoral student studying chemistry with chemistry professor Somenath Mitra at NJIT, received on April 14, 2010, the second-place bronze medal for her graduate entry “Polymer Films Containing Microparticles of Active Pharmaceutical Ingredients for Oral Drug Delivery” at the NJIT Dana Knox Student Research Day Showcase.
Anti-solvent synthesis of micro scale drug particles with simultaneous suspension stabilization using different cellulose derivatives and a surfactant was reported. The process was quite effective under low power ultrasonic agitation.
The mean diameter of the small particles grew with time, while the overall particle size distribution showed a decrease in average particle size due to sedimentation. The result showed that a mixture of cellulose and sodium dodecyl sulfate (SDS) reduced the average particle size more effectively than either only cellulose or SDS. The sedimentation rate was also the lowest when both the cellulose and SDS were used.
Zeta potential measurements showed that the suspensions were close to agglomeration rather than thermodynamically stable. Films of hydroxypropyl methyl cellulose (HPMC), with Griseofulvin (GF) as the model drug were formed by solvent casting of the stabilized suspension. SEM and Raman imaging show that the drug particle shape was uniformly distributed and X-ray diffraction revealed the crystal structure for GF-loaded polymer film remained unchanged during film formation.