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Contact Information: Tanya Klein Public Relations 973-596-3433

Stem Cell, Artificial Liver Research Receives Coulter Foundation Funding at NJIT

Two NJIT biomedical researchers have received the prestigious Coulter Foundation Translational Awards for promising patent applications that may some day extend peoples’ lives. 

The Coulter program provides funding for professors in established biomedical engineering departments within the U.S.  Initial funding for each professor will be at least $200,000 over a two-year period. 

NJIT Associate Professor Treena Arinzeh will receive funding for her patent application to create an electro-spun composite material for bone  repair applications. Her composite material can be combined with stem cells to enhance the rate of bone repair.

NJIT Assistant Professor Cheul Cho will receive support for his patent application for an extracorporeal bio-artificial liver assist device with human stem cell-derived hepatocytes for the treatment of liver failure.  His project aims to differentiate human embryonic stem (ES) cells into functional hepatocytes and to evaluate their therapeutic efficacy in a bio-artificial liver (BAL) for the treatment of acute liver failure. Current potential cell-based therapies and extracorporeal BAL devices for the treatment of liver failure are severely limited by the low availability of functional human liver cells, called hepatocytes.

Arinzeh’s research focuses on tissue engineering, the application of principles and methods of engineering and life sciences toward a fundamental understanding and development of biological substitutes to restore, maintain and improve human tissue functions. Bone regeneration may be achieved by the use of osteogenic cells and/or factors to induce bone growth in combination with an appropriate scaffold to guide and support the laying down of new bone tissue.

Optimally, a scaffold for bone tissue engineering should satisfy the following minimum requirements, she said.  It must be biocompatible, able to coexist with living tissues or organisms without causing harm.  It must have osteoconductivity, able to serve as a scaffold or matrix on which bone cells may attach, migrate and form new bone.  It should have minute openings, pores or holes, so that bone can grow inside the material.  It should be biodegradable, able to break down in the body without causing harm.  And, it should have mechanical integrity—the ability to hold together and withstand chemical, physical, and biological forces.

Cho’s research focuses on designing a clinically-scaled bio-artificial liver. Approximately 10 percent of the liver mass is necessary to support a patient with acute liver failure, which is a critical limitation for many cell-based therapies for liver failure.

Embryonic stem cells are considered a potential source of cells for hepatic therapies due to their limitless capacity for self-renewal and proliferation, and their ability to differentiate into all major cell lineages. 

Cho’s novel method differentiates embryonic stem cells into hepatocytes with high purity. Incorporating these cell-derived hepatocytes into a device to treat fulminant hepatic failure has improved animal survival, thereby underscoring the cells’ therapeutic potential.  (A provisional patent was also filed for this project.)

The Coulter Foundation supports biomedical research that is translational in nature, and it encourages and assists eligible biomedical engineering investigators to establish themselves in academic careers involving translational research. The translational research projects are directed at promising technologies with the goal of progressing toward commercial development and entering clinical practice.

NJIT, New Jersey's science and technology university, enrolls approximately 10,000 students pursuing bachelor's, master's and doctoral degrees in 120 programs. The university consists of six colleges: Newark College of Engineering, College of Architecture and Design, College of Science and Liberal Arts, School of Management, College of Computing Sciences and Albert Dorman Honors College. U.S. News & World Report's 2012 Annual Guide to America's Best Colleges ranked NJIT in the top tier of national research universities. NJIT is internationally recognized for being at the edge in knowledge in architecture, applied mathematics, wireless communications and networking, solar physics, advanced engineered particulate materials, nanotechnology, neural engineering and e-learning. Many courses and certificate programs, as well as graduate degrees, are available online through the Division of Continuing Professional Education.